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Article

Pharmacogenomic Profiling of Cisplatin-Resistant and -Sensitive Human Osteosarcoma Cell Lines by Multimodal Targeted Next Generation Sequencing.

International journal of molecular sciences - 4 Oct 2022

Hattinger Claudia Maria, Casotti Chiara, Patrizio Maria Pia, Luppi Silvia, Fantoni Leonardo, Scotlandi Katia, Ibrahim Toni, Serra Massimo

Abstract excerpt

Cisplatin (CDDP) is a drug for high-grade osteosarcoma (HGOS) treatment. Several germline pharmacogenetic studies have revealed associations between single nucleotide polymorphisms (SNPs) and CDDP-based therapy response or CDDP-related toxicity in patients with HGOS. Whether these variants could play a biological role in HGOS cells has not been studied so far. The aim of this study was to explore 28 SNPs of 14...

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Identifiers

PMID: 36233089
DOI: 10.3390/ijms231911787
PMCID: PMC9570120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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