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Article

Genetic variability of DNA repair mechanisms and glutathione-S-transferase genes influences treatment outcome in osteosarcoma.

Cancer epidemiology - 1 Apr 2015

Goričar Katja, Kovač Viljem, Jazbec Janez, Zakotnik Branko, Lamovec Janez, Dolžan Vita

Abstract excerpt

BACKGROUND: Osteosarcoma patients are commonly treated with cisplatin-based preoperative and postoperative chemotherapy. Cisplatin binds to DNA and forms both intrastrand and interstrand crosslinks, inhibiting DNA replication. Glutathione-S-transferases (GSTs) participate in cisplatin detoxification, while several independent DNA repair mechanisms repair cisplatin-induced lesions. The aim of our study was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25592234
DOI: 10.1016/j.canep.2014.12.009

Genes

EFS
NBN
ERCC2
GSTP1
CGA
ERCC1
GSTM1
GSTT1
RAD51
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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