Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.

Biochimica et biophysica acta - 1 Nov 2016

Socoro-Yuste Nuria, Dagher Marie-Claire, Gonzalez De Peredo Anne, Mondet Julie, Zaccaria Affif, Roux Dalvai Florence, Plo Isabelle, Cahn Jean Yves, Mossuz Pascal

Abstract excerpt

Besides genetic abnormalities in MPN patients, several studies have reported alterations in protein expression that could contribute towards the clinical phenotype. However, little is known about protein modifications in Ph- MPN erythrocytes. In this context, we used a quantitative mass spectrometry proteomics approach to study the MPN erythrocyte proteome. LC-MS/MS (LTQ Orbitrap) analysis led to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calreticulin
Share to cdc42 GTP-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Liquid

Share to p21-Activated Kinases

Share to rac1 GTP-Binding Protein

Share to ras GTPase-Activating Proteins

Share to rhoA GTP-Binding Protein

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 27566291
DOI: 10.1016/j.bbamcr.2016.08.012

Genes

IQGAP1
CALR
JAK2
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.PMID 27566291Read ↗

Quantitative Proteome Heterogeneity in Myeloproliferative Neoplasm Subtypes and Association with JAK2 Mutation Status.Semantic proximity Read ↗

A proteomic study of myeloproliferative neoplasms using reverse-phase protein arrays.Semantic proximity Read ↗

Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles.Semantic proximity Read ↗

Transcriptomic comparison of bone marrow CD34 + cells and peripheral blood neutrophils from ET patients with JAK2 or CALR mutations.Semantic proximity Read ↗

HRAS mutation positive multiple myeloma in the type 2 CALR mutation positive essential thrombocythemia: A case report.Semantic proximity Read ↗

Platelet transcriptome yields progressive markers in chronic myeloproliferative neoplasms and identifies putative targets of therapySemantic proximity Read ↗

Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimensSemantic proximity Read ↗

A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cellsSemantic proximity Read ↗

A rare CALR variant mutation and efficient peginterferon alfa-2a response in a patient with essential thrombocythemia.Semantic proximity Read ↗

CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytesSemantic proximity Read ↗

Single-cell transcriptomic analysis identifies an immune erythroid in paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.