Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens

Abstract excerpt

Impaired protein homeostasis, though well established in age-related disorders, has been linked in recent research with the pathogenesis of myeloproliferative neoplasms (MPNs). As yet, however, little is known about MPN-specific modulators of proteostasis, thus impeding our ability for increased mechanistic understanding and discovery of additional therapeutic targets. Loss of proteostasis, in itself, is traced to...

Topics

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• Calreticulin
• cdc42 GTP-Binding Protein
• Chromatography, Liquid
• p21-Activated Kinases
• rac1 GTP-Binding Protein
• ras GTPase-Activating Proteins
• rhoA GTP-Binding Protein
• Tandem Mass Spectrometry

Identifiers and source

Literature Corpus work

3057568e-cc38-51d8-b9b0-6bac2c3a1401

DOI

10.1101/2023.01.07.523111