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A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells

24 Jun 2016

Abstract excerpt

microRNAs (miRNAs) are relevant in the pathogenesis of primary myelofibrosis (PMF) but our understanding is limited to specific target genes and the overall systemic scenario islacking. By both knowledge-based and ab initio approaches for comparative analysis of CD34+ cells of PMF patients and healthy controls, we identified the deregulated pathways involving miRNAs and genes and new transcriptional and...

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PMID: 27341078
DOI: 10.1038/bcj.2016.47

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