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Article

A rare CALR variant mutation and efficient peginterferon alfa-2a response in a patient with essential thrombocythemia.

Cancer genetics - 1 Jun 2023

Ciftciler Rafiye, Balasar Ozgur

Abstract excerpt

Calreticulin (CALR) is a calcium-binding protein chaperone that may be found throughout the extracellular matrix and membranes of cells. It regulates calcium homeostasis and ensures the appropriate folding of newly generated glycoproteins within the endoplasmic reticulum. A somatic mutation in JAK2, CALR, or MPL is responsible for the great majority of essential thrombocythemia (ET) cases. ET has a diagnostic and...

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Share to Janus Kinase 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36972657
DOI: 10.1016/j.cancergen.2023.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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A rare CALR variant mutation and efficient peginterferon alfa-2a response in a patient with essential thrombocythemia.PMID 36972657Read ↗

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