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Article

NHERF1/EBP50 is a new marker in colorectal cancer.

Neoplasia (New York, N.Y.) - 1 Dec 2010

Hayashi Yuho, Molina Jennifer R, Hamilton Stanley R, Georgescu Maria-Magdalena

Abstract excerpt

Human colorectal cancer (CRC) arises from activating mutations in the Wnt/β-catenin pathway that converge with additional molecular changes to shape tumor development and patient prognosis. We report here that Na(+)/H(+) exchanger 3 regulating factor 1 (NHERF1)/EBP50, an adaptor molecule that interacts with β-catenin, undergoes successive alterations during the colorectal adenoma-to-carcinoma transition, ranging...

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Source

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Identifiers

PMID: 21170265
DOI: 10.1593/neo.10780
PMCID: PMC3003136

Genes

NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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NHERF1/EBP50 is a new marker in colorectal cancer.PMID 21170265Read ↗

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The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancerSemantic proximity Read ↗

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Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiationSemantic proximity Read ↗

NHERF1/EBP50 controls lactation by establishing basal membrane polarity complexes with prolactin receptor.Semantic proximity Read ↗

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progressionSemantic proximity Read ↗

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Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevanceSemantic proximity Read ↗

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