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Article

Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.

Clinical pharmacology and therapeutics - 1 Sept 2014

Bosilkovska M, Samer C F, Déglon J, Rebsamen M, Staub C, Dayer P, Walder B, Desmeules J A, Daali Y

Abstract excerpt

The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) using a cocktail approach. Ten volunteers received an oral cocktail capsule containing low doses of the probes bupropion (CYP2B6), flurbiprofen (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), midazolam (CYP3A), and fexofenadine...

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Identifiers

PMID: 24722393
DOI: 10.1038/clpt.2014.83
PMCID: PMC4151019

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