Article

Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAF <sup>V600E</sup> -induced cellular senescence in human melanocytes

2023-02-17

Abstract excerpt

Melanoma arises from transformation of melanocytes in the basal layer of the epidermis where they are surrounded by keratinocytes, with which they interact through cell contact and paracrine communication. Considerable effort has been devoted to determining how the accumulation of oncogene and tumor suppressor gene mutations in melanocytes drive melanoma development. However, the extent to which alterations in ker...

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Literature Corpus work: 30c3c0e7-6469-52e2-883e-cd03ba4c76d4
DOI: 10.1101/2023.02.16.528886

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