Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.

The Journal of investigative dermatology - 1 Oct 2014

South Andrew P, Purdie Karin J, Watt Stephen A, Haldenby Sam, den Breems Nicoline, Dimon Michelle, Arron Sarah T, Kluk Michael J, Aster Jon C, McHugh Angela, Xue Dylan J, Dayal Jasbani Hs, Robinson Kim S, Rizvi Sm Hasan, Proby Charlotte M, Harwood Catherine A, Leigh Irene M

Abstract excerpt

Cutaneous SCC (cSCC) is the most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here, we use massively parallel exome and targeted level sequencing of 132 sporadic cSCCs and of 39 squamoproliferative lesions and cSCCs arising in patients receiving the BRAF inhibitor vemurafenib, as well as 10 normal skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Indoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor, Notch1

Share to Receptors, Notch

Share to Skin Diseases

Share to Sulfonamides

Share to Vemurafenib

Source

Open in PubMed Open full text

Identifiers

PMID: 24662767
DOI: 10.1038/jid.2014.154
PMCID: PMC4753672

Genes

NOTCH1
BRAF
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.PMID 24662767Read ↗

Mutational landscape of aggressive cutaneous squamous cell carcinoma.Semantic proximity Read ↗

Oh, the Mutations You'll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma.Semantic proximity Read ↗

The landscape of driver mutations in cutaneous squamous cell carcinomaSemantic proximity Read ↗

The landscape of driver mutations in cutaneous squamous cell carcinomaSemantic proximity Read ↗

Comprehensive molecular characterization of cutaneous squamous cell carcinoma reveals determinants of metastatic progressionSemantic proximity Read ↗

Identification of genetic mutations of cutaneous squamous cell carcinoma using whole exome sequencing in non-Caucasian population.Semantic proximity Read ↗

Whole Exome and Transcriptome Sequencing of Stage-Matched, Outcome-Differentiated Cutaneous Squamous Cell Carcinoma Identifies Gene Expression Patterns Associated with Metastasis and Poor OutcomesSemantic proximity Read ↗

Genomic progression for local invasion of cutaneous squamous cell carcinoma from the superficial to the deep portion.Semantic proximity Read ↗

Mutational Landscape of Normal Human Skin: Clues to Understanding Early-Stage Carcinogenesis in Keratinocyte Neoplasia.Semantic proximity Read ↗

Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing.Semantic proximity Read ↗

Mutational Profiles of Cutaneous Squamous Cell Carcinomas with Different Patterns of Clinical Aggression from Head and Neck DistrictSemantic proximity Read ↗

Targeted deep sequencing reveals genomic alterations of actinic keratosis/cutaneous squamous cell carcinoma in situ and cutaneous squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.