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Article

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression

25 Aug 2023

Abstract excerpt

The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies have revealed a massive mutational burden but have yet to illuminate mechanisms of disease progression. Here we perform RNAseq transcriptomic profiling of 110 patient samples...

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PMID: 37626054
DOI: 10.1038/s41467-023-40822-9

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