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Article

Generation of TALEN-mediated FH knockout rat model.

Oncotarget - 20 Sept 2016

Yu Dandan, Zhong Yali, Li Xiaoran, Li Yaqing, Li Xiaoli, Cao Jing, Fan Zhirui, Fan Huijie, Yuan Long, Xu Benling, Yuan Yuan, Zhang Hongquan, Ji Zhenyu, Wen Jian-Guo, Zhang Mingzhi, Nesland Jahn M, Suo Zhenhe

Abstract excerpt

Transcription activator-like effector nucleases (TALENs) are valuable tools for precise genome engineering of laboratory animals. Here we utilized this technique for efficient site-specific gene modification to create a fumarate hydratase (FH) gene knockout rat model, in which there was an 11 base-pair deletion in the first exon of the FH gene in 111 rats. 18 live-born targeted mutation offsprings were produced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Genetically Modified

Share to Gene Knockout Techniques

Share to Genes, Lethal

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Share to Rats, Sprague-Dawley

Share to Transcription Activator-Like Effector Nucleases

Source

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Identifiers

PMID: 27556703
DOI: 10.18632/oncotarget.11429
PMCID: PMC5308680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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