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Article

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

PLoS biology - 1 Aug 2016

Ashton-Beaucage Dariel, Lemieux Caroline, Udell Christian M, Sahmi Malha, Rochette Samuel, Therrien Marc

Abstract excerpt

RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic aspects of RAS-MAPK signal transmission and regulation. While much information has been garnered on the steps leading up to the activation and inactivation of core...

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Source

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Identifiers

PMID: 27552662
DOI: 10.1371/journal.pbio.1002539
PMCID: PMC4994957

Genes

USP47
UBR4
KCMF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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