Article

Residue-specific dominant-negative mutant of ubiquitin reveals functional selectivity as Ubp14 deubiquitinase inhibitor

2026-05-20

Abstract excerpt

Multifunctional proteins encode specificity through nuanced molecular interactions that operate in the presence of abundant wild-type molecules. Previous studies on multifunctional proteins have shown how certain regulated interactions parse complex biological activities into discrete functional modules. Discrete interaction edges can function as regulatory nodes whose perturbations selectively remodel proteostasi...

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Literature Corpus work: 212009d8-497c-5815-b044-8d82f2acd206
DOI: 10.64898/2026.05.18.725830

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