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Article

Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

Cell reports - 6 Nov 2014

Schülein-Völk Christina, Wolf Elmar, Zhu Jing, Xu Wenshan, Taranets Lyudmyla, Hellmann Andreas, Jänicke Laura A, Diefenbacher Markus E, Behrens Axel, Eilers Martin, Popov Nikita

Abstract excerpt

Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates the turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-dependent substrate ubiquitination is antagonized by the Usp28 deubiquitinase. Here, we show that Usp28 preferentially antagonizes aut...

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Identifiers

PMID: 25437563
DOI: 10.1016/j.celrep.2014.09.057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25437563-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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