Article

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

2025-11-12

Abstract excerpt

Axonal and synaptic degeneration are key hallmarks of neurodegenerative diseases, but the underlying molecular mechanisms are incompletely understood. Here, we performed an unbiased forward genetic mosaic screen to identify genes required for maintenance of adult motor axons and neuromuscular junctions (NMJs) in the Drosophila leg. We identified 49 mutations in 30 genes, including mutations in 8 genes resulting i...

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Literature Corpus work: f4fd52b0-15a3-54a2-aebc-6d9407e59ecc
DOI: 10.1101/2025.11.11.687669

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