Article
The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.
FEBS letters - 1 Mar 2017
Ling Xuemei, Huang Qinzhu, Xu Yanqin, Jin Yuxiao, Feng Ying, Shi Weijie, Ye Xiaolei, Lin Yi, Hou Ling, Lin Xinhua
Abstract excerpt
Usp5 belongs to the USP family of deubiquitinating enzymes (DUBs), which comprises the largest class of DUBs. We previously reported that loss of Usp5 impairs development of photoreceptors in Drosophila eyes, although the detailed mechanism remained unclear. In the present study, we demonstrate that Usp5 regulates both Notch and receptor tyrosine kinase (RTK) signaling. Loss of Usp5 results in upregulation of...
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