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Article

Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress

29 Oct 2013

Abstract excerpt

The HDM2-p53 loop is crucial for monitoring p53 level and human pathologies. Therefore, identification of novel molecules involved in this regulatory loop is necessary for understanding the dynamic regulation of p53 and treatment of human diseases. Here, we characterized that the ribosomal protein L6 binds to and suppresses the E3 ubiquitin ligase activity of HDM2, and subsequently attenuates HDM2-mediated p53...

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PMID: 24174547
DOI: 10.1093/nar/gkt971

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