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Article

Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.

Cellular immunology - 1 Jan 2000

Bommireddy Ramireddy, Engle Sandra J, Ormsby Ilona, Boivin Gregory P, Babcock George F, Doetschman Thomas

Abstract excerpt

Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient for the reversal, but elimination of either CD4+ or CD8+ cells is not. Although elimination of B...

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Identifiers

PMID: 15922720
DOI: 10.1016/j.cellimm.2005.02.004
PMCID: PMC2804065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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