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Article

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2006

O'Sullivan Brendan J, Thomas Helen E, Pai Saparna, Santamaria Pere, Iwakura Yoichiro, Steptoe Raymond J, Kay Thomas W H, Thomas Ranjeny

Abstract excerpt

IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is genetically or clinically associated with many others. IL-1 is a pleiotropic proinflammatory cytokine; however the mechanisms by which increased IL-1 signaling promotes autoreactive T cell activity are not clear. Here we...

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PMID: 16751371
DOI: 10.4049/jimmunol.176.12.7278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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