Article
The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase.
Journal of cell science - 1 Oct 2016
Soeda Shou, Yamada-Nomoto Kaori, Ohsugi Miho
Abstract excerpt
Mitotic chromosomes move dynamically along the spindle microtubules using the forces generated by motor proteins such as chromokinesin Kid (also known as KIF22). Kid generates a polar ejection force and contributes to alignment of the chromosome arms during prometaphase and metaphase, whereas during anaphase, Kid contributes to chromosome compaction. How Kid is regulated and how this regulation is important for...
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