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Article

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

Molecular biology of the cell - 1 Jul 2008

Zhang Xin, Ems-McClung Stephanie C, Walczak Claire E

Abstract excerpt

During mitosis, mitotic centromere-associated kinesin (MCAK) localizes to chromatin/kinetochores, a cytoplasmic pool, and spindle poles. Its localization and activity in the chromatin region are regulated by Aurora B kinase; however, how the cytoplasmic- and pole-localized MCAK are regulated is currently not clear. In this study, we used Xenopus egg extracts to form spindles in the absence of chromatin and...

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Identifiers

PMID: 18434591
DOI: 10.1091/mbc.e08-02-0198
PMCID: PMC2441684

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Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.PMID 18434591Read ↗

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