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Article

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.

Acta neuropathologica communications - 22 Aug 2016

Scheffold Annika, Holtman Inge R, Dieni Sandra, Brouwer Nieske, Katz Sarah-Fee, Jebaraj Billy Michael Chelliah, Kahle Philipp J, Hengerer Bastian, Lechel André, Stilgenbauer Stephan, Boddeke Erik W G M, Eggen Bart J L, Rudolph Karl-Lenhard, Biber Knut

Abstract excerpt

Parkinson's disease is one of the most common neurodegenerative disorders of the elderly and ageing hence described to be a major risk factor. Telomere shortening as a result of the inability to fully replicate the ends of linear chromosomes is one of the hallmarks of ageing. The role of telomere dysfunction in neurological diseases and the ageing brain is not clarified and there is an ongoing discussion whether...

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Identifiers

PMID: 27550225
DOI: 10.1186/s40478-016-0364-x
PMCID: PMC4994259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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