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Article

Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes.

Biogerontology - 1 Apr 2024

Harley Jasmine, Santosa Munirah Mohamad, Ng Chong Yi, Grinchuk Oleg V, Hor Jin-Hui, Liang Yajing, Lim Valerie Jingwen, Tee Wee Wei, Ong Derrick Sek Tong, Ng Shi-Yan

Abstract excerpt

Telomere shortening is a well-established hallmark of cellular aging. Telomerase reverse transcriptase (TERT) plays a crucial role in maintaining the length of telomeres, which are specialised protective caps at the end of chromosomes. The lack of in vitro aging models, particularly for the central nervous system (CNS), has impeded progress in understanding aging and age-associated neurodegenerative diseases. In...

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Identifiers

PMID: 37987889
DOI: 10.1007/s10522-023-10076-5
PMCID: PMC10998800

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TERT

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