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Article

Telomere shortening leads to earlier age of onset in ALS mice

24 Feb 2016

Abstract excerpt

Telomere shortening has been linked to a variety of neurodegenerative diseases. Recent evidence suggests that reduced telomerase expression results in shorter telomeres in leukocytes from sporadic patients with amyotrophic lateral sclerosis (ALS) compared with healthy controls. Here, we have characterized telomere length in microglia, astroglia and neurons in human post mortem brain tissue from ALS patients and...

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Share to Muscle Physiology and Disorders
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PMID: 26978042
DOI: 10.18632/aging.100904

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