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Article

Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype.

Neurobiology of aging - 1 Jun 2015

Khan Asif Manzoor, Babcock Alicia A, Saeed Hamid, Myhre Christa Løth, Kassem Moustapha, Finsen Bente

Abstract excerpt

The susceptibility of the aging brain to neurodegenerative disease may in part be attributed to cellular aging of the microglial cells that survey it. We investigated the effect of cellular aging induced by telomere shortening on microglia by the use of mice lacking the telomerase RNA component (TERC) and design-based stereology. TERC knockout (KO) mice had a significantly reduced number of CD11b(+) microglia in...

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Identifiers

PMID: 25892207
DOI: 10.1016/j.neurobiolaging.2015.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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