Article
Immune response-associated gene analysis of 1,000 cancer patients using whole-exome sequencing and gene expression profiling-Project HOPE.
Biomedical research (Tokyo, Japan) - 1 Jan 2016
Akiyama Yasuto, Kondou Ryota, Iizuka Akira, Ohshima Keiichi, Urakami Kenichi, Nagashima Takeshi, Shimoda Yuji, Tanabe Tomoe, Ohnami Sumiko, Ohnami Shumpei, Kusuhara Masatoshi, Mochizuki Tohru, Yamaguchi Ken
Abstract excerpt
Project HOPE (High-tech Omics-based Patient Evaluation) has been progressing since its implementation in 2014 using whole-exome sequencing (WES) and gene expression profiling (GEP). With the aim of evaluating immune status in cancer patients, a gene panel consisting of 164 immune response-associated genes (56 antigen-presenting cell and T-cell-associated genes, 34 cytokine- and metabolism-associated genes, 47 TNF...
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