Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma

20 Dec 2023

Abstract excerpt

Aims DNA damage repair (DDR) plays a pivotal role in hepatocellular carcinoma (HCC), driving oncogenesis, progression, and therapeutic response. However, the mechanisms of DDR mediated immune cells and immuno-modulatory pathways in HCC are yet ill-defined. Methods Our study introduces an innovative deep machine learning framework for precise DDR assessment, utilizing single-cell RNA sequencing (scRNA-seq) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Ferroptosis and cancer prognosis
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38135208
DOI: 10.1016/j.canlet.2023.216594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinomaPMID 38135208Read ↗

DNA damage response-related signatures characterize the immune landscape and predict the prognosis of HCC via integrating single-cell and bulk RNA-sequencingSemantic proximity Read ↗

DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic FeaturesSemantic proximity Read ↗

DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung CancerSemantic proximity Read ↗

DNA damage repair-related gene signature can influence immune status and predict prognosis in hepatocellular carcinomaSemantic proximity Read ↗

Identification of the CD8+T-cell exhaustion signature of Hepatocellular Carcinoma for the Prediction of prognosis and Immune microenvironment by Integrated Analysis of Bulk- and Single-Cell RNA Sequencing DataSemantic proximity Read ↗

Multi-omic analyses of hepatocellular carcinoma to determine immunological characteristics and key nodes in gene-expression network.Semantic proximity Read ↗

DNA damage repair-related gene signature can influence immune status and predict prognosis in hepatocellular carcinomaSemantic proximity Read ↗

Single-Cell Transcriptome Analysis Reveals the Expression Pattern of PDCD10 in Myeloid Cells of Hepatocellular Carcinoma and Its Correlation with Oxidative Stress, Immune Infiltration, and Immunotherapy PrognosisSemantic proximity Read ↗

Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer.Semantic proximity Read ↗

An NK cell-related gene signature reveals hepatocellular carcinoma prognosis and immune landscape through integrated single-cell and bulk RNA sequencingSemantic proximity Read ↗

Integrated analysis identifies disulfidptosis related tumor antigens and molecular subtypes in hepatocellular carcinoma for mRNA vaccine developmentSemantic proximity Read ↗

Breaking Therapeutic Resistance in Hepatocellular Carcinoma: Systems Biology Deconvolution of the B-cell Microenvironment Identifies PDIA6 as a Novel TargetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.