Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit.

doi:10.1038/s41375-019-0691-6

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Article

Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit.

Leukemia - 1 May 2020

Cucco Francesco, Barrans Sharon, Sha Chulin, Clipson Alexandra, Crouch Simon, Dobson Rachel, Chen Zi, Thompson Joe Sneath, Care Matthew A, Cummin Thomas, Caddy Josh, Liu Hongxiang, Robinson Anne, Schuh Anna, Fitzgibbon Jude, Painter Daniel, Smith Alexandra, Roman Eve, Tooze Reuben, Burton Catherine, Davies Andrew J, Westhead David R, Johnson Peter W M, Du Ming-Qing

Abstract excerpt

Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched for MYC/BCL2 double-hit (MYC/BCL2-DH). The genetic basis underlying MHG-DLBCL and their aggressive clinical behaviour remain unknown. We investigated 697 cases of DLBCL, particularly those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Gene Rearrangement

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Proteins c-bcl-2

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Identifiers

PMID: 31844144
DOI: 10.1038/s41375-019-0691-6
PMCID: PMC7192846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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