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Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

13 Sept 2021

Abstract excerpt

The discovery of a new class of small molecule compounds that target the BCL-2 family of anti-apoptotic proteins is one of the great success stories of basic science leading to translational outcomes in the last 30 years. The eponymous BCL-2 protein was identified over 30 years ago due to its association with cancer. However, it was the unveiling of the biochemistry and structural biology behind it and its close...

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PMID: 34515749
DOI: 10.1042/bst20210749

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