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Article

BCL2 mutations in diffuse large B-cell lymphoma.

Leukemia - 1 Jun 2012

Schuetz J M, Johnson N A, Morin R D, Scott D W, Tan K, Ben-Nierah S, Boyle M, Slack G W, Marra M A, Connors J M, Brooks-Wilson A R, Gascoyne R D

Abstract excerpt

BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-κB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary DLBCL biopsies, 131 additional non-Hodgkin lymphoma biopsies, 24 DLBCL cell lines and 51 germline DNAs. We found...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Lymphoma, Mantle-Cell

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Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 22189900
DOI: 10.1038/leu.2011.378

Genes

BCL2
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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