Article
Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging.
Oncotarget - 6 Sept 2016
Tang Xiang, Wu Di, Gu Li-Hua, Nie Bin-Bin, Qi Xin-Yang, Wang Yan-Juan, Wu Fang-Fang, Li Xiao-Li, Bai Feng, Chen Xiao-Chun, Xu Lin, Ren Qing-Guo, Zhang Zhi-Jun
Abstract excerpt
Dysfunction of neuronal activity is a major and early contributor to cognitive impairment in Alzheimer's disease (AD). To investigate neuronal activity alterations at early stage of AD, we encompassed behavioral testing and in vivo manganese-enhanced magnetic resonance imaging (MEMRI) in 5XFAD mice at early ages (1-, 2-, 3- and 5-month). The 5XFAD model over-express human amyloid precursor protein (APP) and...
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