Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures.

Molecular neurodegeneration - 4 Feb 2013

Perez Pablo D, Hall Gabrielle, Kimura Tetsuya, Ren Yan, Bailey Rachel M, Lewis Jada, Febo Marcelo, Sahara Naruhiko

Abstract excerpt

BACKGROUND: Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Brain Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Imaging

Share to Memory

Share to Mice, Transgenic

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 23379588
DOI: 10.1186/1750-1326-8-9
PMCID: PMC3579718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures.PMID 23379588Read ↗

Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging.Semantic proximity Read ↗

Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopy.Semantic proximity Read ↗

Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signatureSemantic proximity Read ↗

Effect size of memory deficits in mice with adult-onset P301L tau expression.Semantic proximity Read ↗

In vivo axonal transport deficits in a mouse model of fronto-temporal dementia.Semantic proximity Read ↗

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of AmyloidosisSemantic proximity Read ↗

Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.Semantic proximity Read ↗

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.Semantic proximity Read ↗

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosisSemantic proximity Read ↗

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.Semantic proximity Read ↗

Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of TauopathySemantic proximity Read ↗

Early memory deficits and extensive brain network disorganization in the <i>App</i> <sup> <i>NL-F</i> </sup> / <i>MAPT</i> double knock-in mouse model of familial Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.