Article
Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years.
Brain : a journal of neurology - 1 Nov 2006
Mondadori Christian R A, Buchmann Andreas, Mustovic Henrietta, Schmidt Conny F, Boesiger Peter, Nitsch Roger M, Hock Christoph, Streffer Johannes, Henke Katharina
Abstract excerpt
Presenilin 1 (PSEN1) mutations cause autosomal dominant familial Alzheimer's disease (FAD). PSEN1 mutation carriers undergo the course of cognitive deterioration, which is typical for sporadic Alzheimer's disease but disease onset is earlier and disease progression is faster. Here, we sought to detect signs of FAD in presymptomatic carriers of the PSEN1 mutation (C410Y) by use of a neuropsychological examination,...
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