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Article

Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease.

Autophagy - 1 Dec 2012

Lachenmayer M Lenard, Yue Zhenyu

Abstract excerpt

Parkinson disease (PD) is the most common neurodegenerative movement disorder and is characterized pathologically by the formation of ubiquitin and SNCA/α-synuclein-containing inclusions (Lewy bodies), dystrophic midbrain dopaminergic (DAergic) terminals, and degeneration of midbrain DAergic neurons. The vast majority of PD occurs sporadically, while approximately 5% of all PD cases are inherited. Genetic...

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Source

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Identifiers

PMID: 22931754
DOI: 10.4161/auto.21859
PMCID: PMC3541297

Genes

SNCA
PARK7
PINK1
UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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