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Article

LAMP2A as a therapeutic target in Parkinson disease

5 Dec 2013

Abstract excerpt

Abnormal aggregation of SNCA/?-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration. One of the main pathways for SNCA degradation is chaperone-mediated autophagy (CMA), a selective form of autophagy, while aberrant SNCA may act as a CMA inhibitor. In the current punctum...

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PMID: 24145820
DOI: 10.4161/auto.26451

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