Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain

30 May 2012

Abstract excerpt

Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic dopamine (DA) terminals, and degeneration of midbrain DA neurons. The precise molecular mechanisms underlying these pathological features remain elusive. Accumulating evidence has implicated dysfunctional autophagy, the cell self-digestion and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Lysosomal Storage Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22649237
DOI: 10.1523/jneurosci.5809-11.2012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the BrainPMID 22649237Read ↗

Dopaminergic Neuron-Specific Autophagy-Deficient Mice.Semantic proximity Read ↗

Autophagy in Parkinson's DiseaseSemantic proximity Read ↗

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired AutophagySemantic proximity Read ↗

Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease.Semantic proximity Read ↗

Role of Autophagy Pathway in Parkinson’s Disease and Related Genetic Neurological DisordersSemantic proximity Read ↗

The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s diseaseSemantic proximity Read ↗

Neuronal autophagy and neurodegenerative diseasesSemantic proximity Read ↗

The emerging role of autophagy in Parkinson's diseaseSemantic proximity Read ↗

Mechanisms of neuronal homeostasis: Autophagy in the axon.Semantic proximity Read ↗

Neuronal autophagy: Going the distance to the axonSemantic proximity Read ↗

Advances in autophagy for Parkinson’s disease pathogenesis and treatmentSemantic proximity Read ↗

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.