Article
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.
Autophagy - 1 Jan 2018
Issa Abdul-Raouf, Sun Jun, Petitgas Céline, Mesquita Ana, Dulac Amina, Robin Marion, Mollereau Bertrand, Jenny Andreas, Chérif-Zahar Baya, Birman Serge
Abstract excerpt
The autophagy-lysosome pathway plays a fundamental role in the clearance of aggregated proteins and protection against cellular stress and neurodegenerative conditions. Alterations in autophagy processes, including macroautophagy and chaperone-mediated autophagy (CMA), have been described in Parkinson disease (PD). CMA is a selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein...
Topics
- Animals
- Animals, Genetically Modified
- Autophagy
- Brain
- Disease Models, Animal
- Drosophila
- Humans
- Locomotion
- Lysosomal-Associated Membrane Protein 2
- Neuroprotection