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Article

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

14 Nov 2012

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disease caused by the interaction of genetic and environmental factors. However, the etiology of PD remains largely unknown. Macroautophagy is known to play an essential role in the degradation of abnormal proteins and organelles. Furthermore, the loss of autophagy-related (Atg) genes results in neurodegeneration and abnormal protein accumulation. Since...

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PMID: 23152632
DOI: 10.1523/jneurosci.0209-12.2012

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