Article
LDL cholesterol still a problem in old age? A Mendelian randomization study.
International journal of epidemiology - 1 Apr 2015
Postmus Iris, Deelen Joris, Sedaghat Sanaz, Trompet Stella, de Craen Anton J M, Heijmans Bastiaan T, Franco Oscar H, Hofman Albert, Dehghan Abbas, Slagboom P Eline, Westendorp Rudi G J, Jukema J Wouter
Abstract excerpt
BACKGROUND: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. METHODS: A weighted...
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