Article
Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.
Blood - 28 Nov 2013
Bernot Kelsie M, Nemer John S, Santhanam Ramasamy, Liu Shujun, Zorko Nicholas A, Whitman Susan P, Dickerson Kathryn E, Zhang Mengzi, Yang Xiaojuan, McConnell Kathleen K, Ahmed Elshafa H, Muñoz Maura R, Siebenaler Ronald F, Marcucci Gabriel G, Mundy-Bosse Bethany L, Brook Daniel L, Garman Sabrina, Dorrance Adrienne M, Zhang Xiaoli, Zhang Jianying, Lee Robert J, Blum William, Caligiuri Michael A, Marcucci Guido
Abstract excerpt
The coexpression of the MLL partial tandem duplication (PTD) and the FLT3 internal tandem duplication (ITD) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML). In mice, a double knock-in (dKI) of Mll(PTD/wt) and Flt3(ITD/wt) mutations induces spontaneous AML with an increase in DNA methyltransferases (Dnmt1, 3a, and 3b) and global DNA methylation index, thereby...
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