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Autophagy a Close Relative of AML Biology

18 Jun 2021

Abstract excerpt

Autophagy, which literally means "eat yourself", is more than just a lysosomal degradation pathway. It is a well-known regulator of cellular metabolism and a mechanism implicated in tumor initiation/progression and therapeutic resistance in many cancers. However, whether autophagy acts as a tumor suppressor or promoter is still a matter of debate. In acute myeloid leukemia (AML), it is now proven that autophagy...

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PMID: 34207482
DOI: 10.3390/biology10060552

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