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Article

Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition.

Leukemia - 1 Nov 2022

Qiu Shaowei, Kumar Harish, Yan Chengcheng, Li Hui, Paterson Andrew J, Anderson Nicholas R, He Jianbo, Yang Jing, Xie Min, Crossman David K, Lu Rui, Welner Robert S, Bhatia Ravi

Abstract excerpt

The FLT3-ITD mutation is associated with poor prognosis in acute myeloid leukemia (AML). FLT3 tyrosine kinase inhibitors (TKIs) demonstrate clinical efficacy but fail to target leukemia stem cells (LSC) and do not generate sustained responses. Autophagy is an important cellular stress response contributing to hematopoietic stem cells (HSC) maintenance and promoting leukemia development. Here we investigated the...

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Identifiers

PMID: 36220999
DOI: 10.1038/s41375-022-01719-6
PMCID: PMC9617791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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