Article
Structure-function relationships of archaeal Cbf5 during in vivo RNA-guided pseudouridylation.
RNA (New York, N.Y.) - 1 Oct 2016
Majumder Mrinmoyee, Bosmeny Michael S, Gupta Ramesh
Abstract excerpt
In Eukarya and Archaea, in addition to protein-only pseudouridine (Ψ) synthases, complexes containing one guide RNA and four proteins can also produce Ψ. Cbf5 protein is the Ψ synthase in the complex. Previously, we showed that Ψ's at positions 1940, 1942, and 2605 of Haloferax volcanii 23S rRNA are absent in a cbf5-deleted strain, and a plasmid-borne copy of cbf5 can rescue the synthesis of these Ψ's. Based on...
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