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Article

RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p.

Genetics - 1 May 2008

Hoskins Jason, Butler J Scott

Abstract excerpt

The chemotherapeutic drug 5-fluorouracil (5FU) disrupts DNA synthesis by inhibiting the enzymatic conversion of dUMP to dTMP. However, mounting evidence indicates that 5FU has important effects on RNA metabolism that contribute significantly to the toxicity of the drug. Strains with mutations in nuclear RNA-processing exosome components, including Rrp6p, exhibit strong 5FU hypersensitivity. Studies also suggest...

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Identifiers

PMID: 18493057
DOI: 10.1534/genetics.107.082727
PMCID: PMC2390612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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