The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

doi:10.1007/s00125-016-4077-2

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Article

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Diabetologia - 1 Nov 2016

Xia Qianghua, Chesi Alessandra, Manduchi Elisabetta, Johnston Brian T, Lu Sumei, Leonard Michelle E, Parlin Ursula W, Rappaport Eric F, Huang Peng, Wells Andrew D, Blobel Gerd A, Johnson Matthew E, Grant Struan F A

Abstract excerpt

AIMS/HYPOTHESIS: One of the most strongly associated type 2 diabetes loci reported to date resides within the TCF7L2 gene. Previous studies point to the T allele of rs7903146 in intron 3 as the causal variant at this locus. We aimed to identify the actual gene(s) under the influence of this variant. METHODS: Using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9...

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PMID: 27539148
DOI: 10.1007/s00125-016-4077-2

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ACSL5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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