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Article

Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2021

Kehayova Yulia S, Watson Emily, Wilkinson J Mark, Loughlin John, Rice Sarah J

Abstract excerpt

OBJECTIVE: The osteoarthritis (OA)-associated single-nucleotide polymorphism (SNP) rs11583641 is located in COLGALT2, encoding a posttranslational modifier of collagen. In cartilage, the SNP genotype correlates with DNA methylation in a putative enhancer. This study was undertaken to characterize the mechanistic relationship between rs11583641, the putative enhancer, and COLGALT2 expression using cartilage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage, Articular

Share to Chondrocytes

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Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Galactosyltransferases

Share to Osteoarthritis

Share to Promoter Regions, Genetic

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Identifiers

PMID: 33760386
DOI: 10.1002/art.41738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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