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Article

cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.

PloS one - 1 Jan 2012

Loo Lenora W M, Cheng Iona, Tiirikainen Maarit, Lum-Jones Annette, Seifried Ann, Dunklee Lucas M, Church James M, Gryfe Robert, Weisenberger Daniel J, Haile Robert W, Gallinger Steven, Duggan David J, Thibodeau Stephen N, Casey Graham, Le Marchand Loïc

Abstract excerpt

Genome-wide association studies (GWAS) have identified 19 risk variants associated with colorectal cancer. As most of these risk variants reside outside the coding regions of genes, we conducted cis-expression quantitative trait loci (cis-eQTL) analyses to investigate possible regulatory functions on the expression of neighboring genes. Forty microsatellite stable and CpG island methylator phenotype-negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22363440
DOI: 10.1371/journal.pone.0030477
PMCID: PMC3281844

Genes

DDX28
DLGAP5
NOL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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