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Article

Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations.

Journal of medical genetics - 1 Dec 2016

Goffinet Laetitia, Oussalah Abderrahim, Guéant-Rodriguez Rosa-Maria, Chery Céline, Basha Mirta, Avogbe Patrice Hodonou, Josse Thomas, Jeannesson Elise, Rouyer Pierre, Flayac Justine, Gerard Philippe, Le Touze Anne, Bonin-Goga Béatrice, Goga Dominique, Simon Etienne, Feillet François, Vikkula Miikka, Guéant Jean-Louis

Abstract excerpt

BACKGROUND: Orofacial cleft (OFC) is the most prevalent craniofacial birth defect. Genes involved in one-carbon, folate and vitamin B12 metabolisms have been associated with OFC but no study performed a concomitant assessment on genes involved in these three pathways. OBJECTIVE: We looked for potential genetic variants associated with OFC using an exhaustive gene panel of one-carbon metabolism. METHODS: We...

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Identifiers

PMID: 27535090
DOI: 10.1136/jmedgenet-2016-104111

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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