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Evidence of the folate-mediated one-carbon metabolism pathway genes in controlling the non-syndromic oral clefts risks.

Oral diseases - 1 Apr 2023

Wang Siyue, Shi Jiayu, Liu Chunfang, Wang Ping, Wang Mengying, Li Wenyong, Zhou Ren, Zheng Hongchen, Jiang Jin, Li Nan, Li Jing, Zhou Zhibo, Zhu Hongping, Wu Yiqun, Jia Zhonglin, Wu Tao, Hu Yonghua, Beaty Terri H

Abstract excerpt

The folate-mediated one-carbon metabolism pathway is thought to play an important role in the etiology of non-syndromic oral clefts (NSOFC), although none of the genes in this pathway has shown significant signals in genome-wide association studies (GWAS). Recent evidence indicated that enhanced understanding could be gained by aggregating multiple SNPs effect simultaneously into polygenic risk score (PRS) to...

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PMID: 34739175
DOI: 10.1111/odi.14068

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